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Vioxx was evaluated for the treatment of the signs and symptoms of Osteoarthritis of the knee and hip.
The effectiveness of placebo (sugar pill) was compared with
VIOXX treated patients in controlled clinical trials of 6 to 86
weeks duration that enrolled approximately 3900 patients. In patients with
Osteoarthritis, treatment with VIOXX 25mg and 12.5mg once
daily resulted in an improvement in patient and physician assessments in
Osteoarthritis severity taking into account joint pain, stiffness,
and range of motion measures. In six studies of pain accompanying
Osteoarthritis flare, VIOXX provided a significant reduction
in joint pain at the first determination (after one week in one study,
after two weeks in the remaining five studies); this continued for the
duration of the studies. In all Osteoarthritis clinical studies,
once daily treatment in the morning with VIOXX 25mg and 12.5mg was
associated with a significant reduction in joint stiffness upon first
awakening in the morning.
The patients experienced Osteoarthritis symptoms from the following categories:
- joint pain
- joint stiffness
- range of motion
- knee pain
- hip pain
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