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OSTEOARTHRITIS TREATMENT:
The effectiveness of
CELEBREX was evaluated for the treatment of the signs and symptoms
of Osteoarthritis of the knee and hip. To make this determination a
placebo (sugar pill) was compared with CELEBREX treated patients in
controlled clinical trials involving approximately 4,200 patients with
Osteoarthritis. The clinical trials lasted up to 12 weeks in
duration. In patients with Osteoarthritis, treatment with
CELEBREX 100 mg BID or 200 mg one time each day resulted in an
improvement in patient and physician assessments in Osteoarthritis
severity taking into account joint pain, stiffness, and range of motion
measures. In three 12-week studies of joint pain accompanying
Osteoarthritis flare, CELEBREX doses of 100 mg given twice
daily and 200 mg given twice daily provided significant reduction of pain
within 24-48 hours of initiation of dosing. A total daily dose of 200 mg
has been shown to be equally effective whether administered as 100 mg
twice a day or 200 mg once a day.
The patients experienced Osteoarthritis symptoms from the following categories:
- joint pain
- joint stiffness
- range of motion
- knee pain
- hip pain
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